Hypersensitivity Reactions to Proton Pump Inhibitors

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Hypersensitivity reactions to proton pump inhibitors.

PURPOSE OF REVIEW Proton pump inhibitors (PPI) are one of most frequently prescribed drugs in the world. The purpose of this review is to describe the hypersensitivity reactions to PPI. RECENT FINDINGS Hypersensitivity reactions to PPI vary from mild symptoms to life-threatening disorders. Cases of urticaria, angioedema, anaphylaxis, cytopenia, vasculitis, acute allergic interstitial nephriti...

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Anaphylactic reactions to proton-pump inhibitors.

OBJECTIVE To report two cases of anaphylactic reactions to proton-pump inhibitors (PPIs). CASE SUMMARIES A 54-year-old woman who had taken omeprazole in the past was treated with omeprazole 40 mg and developed periorbital edema, edema of the skin, pruritus, nausea, and vomiting about 45 minutes after taking one capsule. Five months later, she was treated with lansoprazole 30-mg capsules. Agai...

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Management of Hypersensitivity Reactions to Proton Pump Inhibitors: A Retrospective Experience.

BACKGROUND We previously reported perfect specificity and low sensitivity of skin tests in proton pump inhibitor (PPI)-induced immediate hypersensitivity reactions in a prospective multicenter study. Here, in a retrospective study, we aimed to further evaluate the diagnostic workup procedures and characteristics of the patients with suspected PPI hypersensitivity. METHODS This national multic...

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Hypersensitivity to proton pump inhibitors: lansoprazole-induced Kounis syndrome.

Proton pump inhibitors are commonly used in clinical practice for the treatment of peptic ulcer and gastroesophageal reflux and are well tolerated by the patients. Their use is rarely associated with hypersensitivity and anaphylactic reactions. According to the reports in the Uppsala Monitoring Center database the frequency of hypersensitivity reactions out of all reported adverse reactions for...

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Hypersensitivity to lansoprazole with tolerance to other proton pump inhibitors: does cross-reactivity between proton pump inhibitors really exist?

Protection of human and animal subjects. The authors declare that the procedures followed were in accordance with the regulations of the responsible Clinical Research Ethics Committee and in accordance with those of the World Medical Association and the Helsinki Declaration. Confidentiality of data. The authors declare that they have followed the protocols of their work centre on the publicatio...

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ژورنال

عنوان ژورنال: Current Treatment Options in Allergy

سال: 2015

ISSN: 2196-3053

DOI: 10.1007/s40521-015-0046-0